Go Back
+ servings
john wayne casserole in a casserole dish
Print Recipe Add to Collection
4.67 from 3 votes

John Wayne Casserole

John Wayne casserole is a Tex-Mex inspired casserole that layers taco-seasoned ground beef, veggies, cheese, and a creamy sauce over a biscuit dough base. It’s destined to become a family favorite!
Prep Time20 minutes
Cook Time30 minutes
Course: Main Course
Cuisine: American
Keyword: casserole, casserole dish, cheesy casserole, ground beef, taco seasoning
Servings: 12
Calories: 412kcal


  • 2 pounds ground beef
  • 1 1 oz packet taco seasoning or my homemade taco seasoning
  • ¾ cups water
  • 2 ¼ cups Bisquick mix
  • cup water
  • ½ cup mayonnaise
  • ½ cup sour cream
  • 1 cup sharp cheddar cheese shredded and divided
  • 1 small onion diced
  • 1 green pepper diced
  • 2 roma tomatoes diced
  • 1 1 oz can green chiles


  • Preheat oven to 325 degrees F. Spray a 9 x 13 inch baking dish with non-stick cooking spray.
  • Brown ground beef until no longer pink, drain grease. Then add taco seasoning and water and let simmer for 3-4 minutes.
  • In a medium bowl mix sour cream, mayo, half of the cheese, and half of the onion together and set aside.
  • In another bowl, mix together biscuit mix and water to make a soft dough. Press dough into the bottom and 1/2" up the sides of greased 9 x 13 inch pan.
  • Saute remaining onions and green peppers until tender.
  • On top of the biscuit, layer the remaining ingredients in this order: ground beef, diced tomatoes, green peppers and onions, green chilies, sour cream mixture, and remaining cheddar cheese.
  • Bake for 30-35 minutes or until edges are slightly browned.


Calories: 412kcal | Carbohydrates: 16g | Protein: 18g | Fat: 31g | Saturated Fat: 11g | Polyunsaturated Fat: 5g | Monounsaturated Fat: 11g | Trans Fat: 1g | Cholesterol: 73mg | Sodium: 466mg | Potassium: 307mg | Fiber: 1g | Sugar: 4g | Vitamin A: 284IU | Vitamin C: 10mg | Calcium: 136mg | Iron: 2mg