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john wayne casserole in a casserole dish
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John Wayne Casserole

John Wayne casserole is a Tex-Mex inspired casserole that layers taco-seasoned ground beef, veggies, cheese, and a creamy sauce over a biscuit dough base. It’s destined to become a family favorite!
Course Main Course
Cuisine American
Keyword casserole, casserole dish, cheesy casserole, ground beef, taco seasoning
Prep Time 20 minutes
Cook Time 30 minutes
Servings 12
Calories 412kcal
Author Kasey Schwartz


  • 2 pounds ground beef
  • 1 1 oz packet taco seasoning or my homemade taco seasoning
  • ¾ cups water
  • 2 ¼ cups Bisquick mix
  • cup water
  • ½ cup mayonnaise
  • ½ cup sour cream
  • 1 cup sharp cheddar cheese shredded and divided
  • 1 small onion diced
  • 1 green pepper diced
  • 2 roma tomatoes diced
  • 1 1 oz can green chiles


  • Preheat oven to 325 degrees F. Spray a 9 x 13 inch baking dish with non-stick cooking spray.
  • Brown ground beef until no longer pink, drain grease. Then add taco seasoning and water and let simmer for 3-4 minutes.
  • In a medium bowl mix sour cream, mayo, half of the cheese, and half of the onion together and set aside.
  • In another bowl, mix together biscuit mix and water to make a soft dough. Press dough into the bottom and 1/2" up the sides of greased 9 x 13 inch pan.
  • Saute remaining onions and green peppers until tender.
  • On top of the biscuit, layer the remaining ingredients in this order: ground beef, diced tomatoes, green peppers and onions, green chilies, sour cream mixture, and remaining cheddar cheese.
  • Bake for 30-35 minutes or until edges are slightly browned.


Calories: 412kcal | Carbohydrates: 16g | Protein: 18g | Fat: 31g | Saturated Fat: 11g | Polyunsaturated Fat: 5g | Monounsaturated Fat: 11g | Trans Fat: 1g | Cholesterol: 73mg | Sodium: 466mg | Potassium: 307mg | Fiber: 1g | Sugar: 4g | Vitamin A: 284IU | Vitamin C: 10mg | Calcium: 136mg | Iron: 2mg